Reboxetine is the active ingredient in the composition of Vestra along with other inactive ingredients. It belongs to a class of drugs known as Norepinephrine Reuptake Inhibitor (NRI). Vestra [Reboxetine] is an antidepressant drug used for the treatment of clinical depression, panic disorder and attention-deficit hyperactivity disorder (ADHD). It comes in a form of tablets of two different strengths, 2mg and 4mg of reboxetine. Vestra [Reboxetine] works on nerve cells in the brain. In the brain there are different and numerous chemical compounds called as neurotransmitters which act as chemical messengers between nerve cells. Norepinephrine is one such neurotransmitter. When norepinephrine is released from the nerve cells in the brain it acts to lighten the mood. But when it is reabsorbed into the nerve cells it no longer has the effects on mood. When depression occurs, there is a decreased amount of release of norepinephrine from the nerve cells in the brain. Vestra [Reboxetine] works by preventing norepinephrine getting reabsorbed back in the nerve cells in the brain. It helps in prolonged mood lightening effect and thus helps in relieving depression.
How to use
The benefit of Vestra [Reboxetine] is seen after two to four weeks from the starting of the treatment.
The recommended initial dosage of Vestra [Reboxetine] for adults is 4mg twice daily, a total of 8mg a day. The dosage can be increased to 10mg a day after 3 weeks of treatment, if, there is an incomplete clinical response.
The recommended initial dosage of Vestra [Reboxetine] for elderly above 65 years of age is 2mg twice daily, a total of 4mg a day. The dosage can be increased to 6mg a day after 3 weeks of treatment, if, there is an incomplete clinical response.
The recommended initial dosage of Vestra [Reboxetine] for patients with liver and/or kidney disorders is 2mg twice daily, a total of 4mg a day. The dosage can be increased based on the patient’s tolerance.
Side Effects
The most common side effects known to be associated with Vestra [Reboxetine] are insomnia, dry mouth, constipation and sweating.
Other common side effects are headache, blurred vision, dizziness, vertigo, loss of appetite, palpitations, tachycardia, postural hypotension, flushing; difficulty in passing urine, urinary tract infections, chills, impotence, pain in ejaculation, delayed ejaculation or pain in testicles.
Rare and uncommon side effects are irritability, aggressive behavior, agitation, anxiety, cold hands and feet, pins and needles sensations, nausea, vomiting, rash and hypertension.
Drug Interaction
Concomitant use of Vestra [Reboxetine] and diuretics may decrease the level of potassium in blood.
Concomitant use of Vestra [Reboxetine] and ergot derivatives may cause hypertension.
Concomitant use of Vestra [Reboxetine] and sibutramine is not recommended.
Concomitant use of Vestra [Reboxetine] and some drugs may prevent the breakdown of reboxetine by the liver and increase the risk of its side effects. Those drugs are azole antifungals, macrolide antibiotics, nefazodone and fluvoxamine.
Concomitant use of Vestra [Reboxetine] and Mono-Amine Oxidase Inhibitor (MAOI) is not recommended.
Notes
b Patient should be monitored closely whilst on a course with this medication /b
Uses
Vestra [Reboxetine] is used for the treatment of various depressive illness or major depression.
Storage
Vestra [Reboxetine] tablets should be stored at a temperature between 15°-30°C (59°-86°F), preferably below 25°C (77°F).
Precaution
Patient taking Vestra [Reboxetine] should be cautious about driving and operating machineries.
Elderly patients should be cautious taking this drug because intake of this drug may decrease the amount of sodium in blood and can cause symptoms like drowsiness, confusion and muscle twitching.
Vestra [Reboxetine] is not recommended for children under 18 years as it may increase the risk of anger, aggression and suicidal thoughts.
Patients with history of seizures, urinary retention, enlarged prostate gland, heart disease, glaucoma and decrease liver and kidney functions should be cautious and consult the physician before administering the medication.
Pregnant women and lactating mothers should be cautious and consult the physician before taking the medicine.
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