Tofranil [imipramine hydrochloride] belongs to the category of dibenzazepine compounds and is a tricyclic antidepressant that is used for curing variety of psychiatric problems including depression and mental mood swings. Tofranil [imipramine hydrochloride] helps in suppressing and preventing suicidal thoughts and provide numerous other benefits. However during the initial course of treatment patients using Tofranil [imipramine hydrochloride] can experience violent mood swings and increase depression. Hence one must talk to the doctor about all the risks and benefits that are associated with Tofranil [imipramine hydrochloride] usage before starting with this medicine.
When starting with Tofranil [imipramine hydrochloride] it is essential that you talk to your psychiatrist about all the possible treatment choices that are available to you. Special care should be taken by the family members of the patients suffering from bipolar disorder when starting with Tofranil [imipramine hydrochloride] as they may experience higher suicidal thoughts during the initial course of treatment. A careful monitoring is therefore required of all the patients when they begin administering Tofranil [imipramine hydrochloride] doses.
The prescribed doses of Tofranil [imipramine hydrochloride] depend upon the medical history of the patient and their age. During the initial days of treatment the patient should be carefully monitored to notice sudden changes in behavior, mood, feelings and thoughts and every small change should immediately be brought to the notice of the healthcare provider. Also one must be punctual in attending follow up visits and call your doctor if you observe any symptoms that raise concerns.
Tofranil [imipramine hydrochloride] users should inform the doctor about all the medications that they are currently taking before starting with this tablet as it can interact negatively with many medicines. For best results only recommended dosage of medicines should be taken at scheduled intervals. Overdose of the medicine should be avoided and one must never stop taking this medicine abruptly as it can cause severe withdrawal symptoms.
Tofranil [imipramine hydrochloride] is approved by FDA.
How to use
The dose of imipramine is tailored to the patient's needs. Sometimes, physicians will start with low doses, such as 25mg, three times a day, to reduce the risk of excessive sedation; doses then will be increased slowly. Other physicians prefer to give imipramine once daily, in which case it is generally given at bedtime to take advantage of its sedating properties. Elderly persons and patients with advanced liver disease may need lower doses since they may eliminate imipramine less well from the body. Mood elevation occurs only in depressed individuals and not in individuals without depression. It may take 2-3 weeks of therapy before effects are seen.
For the treatment of enuresis, children 6 years or older usually are started on 10-25 mg, at bedtime. If this dose is not effective after 1 week, the dose may be increased by 25 mg/day.
For the treatment of attention-deficit hyperactivity disorder (ADHD), children ages 6-12 years old usually are started on 10-30 mg/day.
Side Effects
The most commonly encountered side effects associated with imipramine include fast heart rate, blurred vision, urinary difficulty urinating, dry mouth, constipation, weight gain or loss, and low blood pressure when standing. Rash, hives, seizures, and hepatitis are rare side effects. Imipramine also can cause elevated pressure in the eyes of some patients with glaucoma. Overdose with imipramine can cause life-threatening abnormal heart rhythms or seizures.
Following prolonged therapy in high doses, abrupt discontinuation of TCAs, including imipramine, could lead to certain cholinergic symptoms such as nausea, vomiting, or diarrhea. Therefore, many experts recommend gradually reducing the dose of drug if the drug is to be discontinued.
Drug Interaction
Imipramine interacts with other medications and drugs that slow the brain's processes, such as alcohol, barbiturates, benzodiazepines, e.g. lorazepam (Ativan), diazepam (Valium), temazepam (Restoril), oxazepam (Serax), clonazepam (Klonopin), zolpidem (Ambien), and narcotics. Reserpine, given to patients taking TCAs, can cause agitation and anxiety. Imipramine and other TCAs should not be used with monoamine oxidase inhibiting drugs, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane), since high fever, convulsions and even death can occur.
Concurrent use of cimetidine (Tagamet) can increase imipramine blood levels by reducing elimination of imipramine from the body and possibly lead to imipramine- related side effects. Other drugs which share this effect include propafenone (Rythmol), flecainide (Tonocard), quinidine (Quinidex, Quinaglute), and fluoxetine (Prozac).
Uses
Tofranil [imipramine hydrochloride] is used for treating depression, panic disorders, anxiety as well as certain kinds of aches and pains. This medicine is also found effective in controlling night time bed wetting in children.
Other Uses
Imipramine is also used occasionally to treat chronic pain, eating disorders, and panic disorders. Talk to your doctor about the possible risks of using this drug for your condition.
Storage
Imipramine should be stored below 86?F (30?C) in a tight, light resistant container.
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